Stay near the banks of the Ohio and Mississippi rivers at the Quality Inn hotel in Cairo, Illinois.

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Cairo ( KAIR-oh) is the southernmost city in Illinois and the county seat of Alexander County. The city is located at the confluence of the Ohio and Mississippi rivers. See more information from the Quality Inn Cairo in the Cairo, Illinois. Fort Defiance, a Civil War camp, was built at the confluence in 1862 by Union General Ulysses S. Book the Quality Inn Cairo in the Cairo, Illinois. Grant to control strategic access to the river. Quality Inn Cairo in the Cairo, Illinois on the detailed map. Cairo has the lowest elevation of any location in Illinois and is the only Illinois city to be surrounded by levees. Quality Inn Cairo in the Cairo, Illinois on the detailed map. It is in the area of Southern Illinois known as Little Egypt. Several blocks in the town comprise the Cairo Historic District, listed on the National Register of Historic Places (NRHP). See more information from the Quality Inn Cairo in the Cairo, Illinois. The Old Customs House is also on the NRHP. See more information from the Quality Inn Cairo in the Cairo, Illinois. The city is part of the Cape Girardeau–Jackson, MO–IL Metropolitan Statistical Area. Book the Quality Inn Cairo in the Cairo, Illinois. Being bypassed by transportation changes and industrial restructuring cost many jobs: the population at the 2020 census was 1,733. Book the Quality Inn Cairo in the Cairo, Illinois. The city's peak population was 15,203 in 1920. The entire city was evacuated during the 2011 Mississippi River Floods, after the Ohio River rose higher than the 1937 flood levels, with the possibility of 15 feet of water inundating Cairo. Book the Quality Inn Cairo in the Cairo, Illinois. The United States Army Corps of Engineers breached levees in the Mississippi flood zone below Cairo in Missouri to prevent flooding in Cairo and other more populous areas further upstream along both the Ohio and Mississippi rivers.. Book the Quality Inn Cairo in the Cairo, Illinois.